Clinical case of steroid-dependent nephrotic syndrome in a child

Nephrotic syndrome (NS) is a common glomerular pathology encountered in pediatric practice. The main clinical signs are massive proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Among all cases of NS, 75 % children have histological variant lesions the form minimal change di­sease that sensitive to hormone therapy, but easily leads relapse steroid dependence. These often need extend time taking hormonal drugs or add other immunosuppressants, which can significant toxicity. Available immunosuppressant treatment options include cyclophosphamide, cyclosporine A, tacrolimus, mycophenolate mofetil. use rituximab possible alternative for steroid-dependent nephrotic children. However, efficacy safety ritu­ximab childhood still controversial. purpose was evaluate child with on example case from our own